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Central project for quantitative biomedical imaging

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Project content

The quantification of biochemical and biophysical tissue properties by means of medical imaging is crucial for improving diagnoses and therapy decisions. Quantitative imaging is the central technology within the SFB for all subprojects related to the in vivo characterisation of tissue matrix changes due to pathological processes. C03 provides all SFB projects with up-to-date imaging technologies for the acquisition of quantitative tissue-intrinsic parameters for the characterisation of pathologically altered ECM, i.e. measurement performance and training of new methods, test and reference objects, elastography hardware, as well as standardised measurement, reconstruction and data processing.

Our team

Project Lead:
Prof. Dr. rer. nat. Ingolf Sack
Prof. Dr. rer. nat. Tobias Schäffter

PhD Candidates (PhD) and Postdoctoral Researchers (PostDoc):


  • Paysen H, Loewa N, Stach A, Wells J, Kosch O, Twamley S, Makowski MR, Schaeffter T, Ludwig A, Wiekhorst F. Cellular uptake of magnetic nanoparticles imaged and quantified by magnetic particle imaging. Sci Rep. 2020 Feb 5;10(1):1922. doi: 10.1038/s41598-020-58853-3. PMID: 32024926; PMCID: PMC7002802.

  • Silva RV, Morr AS, Mueller S, Koch SP, Boehm-Sturm P, Rodriguez-Sillke Y, Kunkel D, Tzschätzsch H, Kühl AA, Schnorr J, Taupitz M, Sack I, Infante-Duarte C. Contribution of Tissue Inflammation and Blood-Brain Barrier Disruption to Brain Softening in a Mouse Model of Multiple Sclerosis. Front Neurosci. 2021 Aug 23;15:701308. doi: 10.3389/fnins.2021.701308. PMID: 34497486; PMCID: PMC8419310.

  • Garczyńska K, Tzschätzsch H, Assili S, Kühl AA, Häckel A, Schellenberger E, Berndt N, Holzhütter HG, Braun J, Sack I, Guo J. Effect of Post-mortem Interval and Perfusion on the Biophysical Properties of ex vivo Liver Tissue Investigated Longitudinally by MRE and DWI. Front Physiol. 2021 Aug 3;12:696304. doi: 10.3389/fphys.2021.696304. PMID: 34413787; PMCID: PMC8369239.

  • Garczyńska K, Tzschätzsch H, Kühl AA, Morr AS, Lilaj L, Häckel A, Schellenberger E, Berndt N, Holzhütter HG, Braun J, Sack I, Guo J. Changes in Liver Mechanical Properties and Water Diffusivity During Normal Pregnancy Are Driven by Cellular Hypertrophy. Front Physiol. 2020 Nov 23;11:605205. doi: 10.3389/fphys.2020.605205. PMID: 33329058; PMCID: PMC7719759.

  • Herthum H, Shahryari M, Tzschätzsch H, Schrank F, Warmuth C, Görner S, Hetzer S, Neubauer H, Pfeuffer J, Braun J, Sack I. Real-Time Multifrequency MR Elastography of the Human Brain Reveals Rapid Changes in Viscoelasticity in Response to the Valsalva Maneuver. Front Bioeng Biotechnol. 2021 May 5;9:666456. doi: 10.3389/fbioe.2021.666456. PMID: 34026743; PMCID: PMC8131519.

  • Kreft B, Bergs J, Shahryari M, Danyel LA, Hetzer S, Braun J, Sack I, Tzschätzsch H. Cerebral Ultrasound Time-Harmonic Elastography Reveals Softening of the Human Brain Due to Dehydration. Front Physiol. 2021 Jan 11;11:616984. doi: 10.3389/fphys.2020.616984. PMID: 33505319; PMCID: PMC7830390.

  • Streitberger KJ, Lilaj L, Schrank F, Braun J, Hoffmann KT, Reiss-Zimmermann M, Käs JA, Sack I. How tissue fluidity influences brain tumor progression. Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):128-134. doi: 10.1073/pnas.1913511116. Epub 2019 Dec 16. PMID: 31843897; PMCID: PMC6955323.

  • Schrank F, Warmuth C, Tzschätzsch H, Kreft B, Hirsch S, Braun J, Elgeti T, Sack I. Cardiac-gated steady-state multifrequency magnetic resonance elastography of the brain: Effect of cerebral arterial pulsation on brain viscoelasticity. J Cereb Blood Flow Metab. 2020 May;40(5):991-1001. doi: 10.1177/0271678X19850936. Epub 2019 May 29. PMID: 31142226; PMCID: PMC7181097.

  • Mohtashamdolatshahi A, Kratz H, Kosch O, Hauptmann R, Stolzenburg N, Wiekhorst F, Sack I, Hamm B, Taupitz M, Schnorr J. In vivo magnetic particle imaging: angiography of inferior vena cava and aorta in rats using newly developed multicore particles. Sci Rep. 2020 Oct 14;10(1):17247. doi: 10.1038/s41598-020-74151-4. PMID: 33057029; PMCID: PMC7560824.

  • Möckel J, Brangsch J, Reimann C, Kaufmann JO, Sack I, Mangarova DB, Kader A, Taupitz M, Adams LC, Keller S, Ludwig A, Hamm B, Botnar RM, Makowski MR. Assessment of Albumin ECM Accumulation and Inflammation as Novel In Vivo Diagnostic Targets for Multi-Target MR Imaging. Biology (Basel). 2021 Sep 27;10(10):964. doi: 10.3390/biology10100964. PMID: 34681063; PMCID: PMC8533611.

  • Kader A, Brangsch J, Kaufmann JO, Zhao J, Mangarova DB, Moeckel J, Adams LC, Sack I, Taupitz M, Hamm B, Makowski MR. Molecular MR Imaging of Prostate Cancer. Biomedicines. 2020 Dec 22;9(1):1. doi: 10.3390/biomedicines9010001. PMID: 33375045; PMCID: PMC7822017.

  • Gültekin E, Wetz C, Braun J, Geisel D, Furth C, Hamm B, Sack I, Marticorena Garcia SR. Added Value of Tomoelastography for Characterization of Pancreatic Neuroendocrine Tumor Aggressiveness Based on Stiffness. Cancers (Basel). 2021 Oct 15;13(20):5185. doi: 10.3390/cancers13205185. PMID: 34680334; PMCID: PMC8533708.

  • Wang S, Millward JM, Hanke-Vela L, Malla B, Pilch K, Gil-Infante A, Waiczies S, Mueller S, Boehm-Sturm P, Guo J, Sack I, Infante-Duarte C. MR Elastography-Based Assessment of Matrix Remodeling at Lesion Sites Associated With Clinical Severity in a Model of Multiple Sclerosis. Front Neurol. 2020 Jan 13;10:1382. doi: 10.3389/fneur.2019.01382. PMID: 31998225; PMCID: PMC6970413.

  • Keller S, Chapiro J, Brangsch J, Reimann C, Collettini F, Sack I, Savic LJ, Hamm B, Goldberg SN, Makowski M. Quantitative MRI for Assessment of Treatment Outcomes in a Rabbit VX2 Hepatic Tumor Model. J Magn Reson Imaging. 2020 Sep;52(3):668-685. doi: 10.1002/jmri.26968. Epub 2019 Nov 12. PMID: 31713973.

  • Burkhardt C, Tzschätzsch H, Schmuck R, Bahra M, Jürgensen C, Pelzer U, Hamm B, Braun J, Sack I, Marticorena Garcia SR. Ultrasound Time-Harmonic Elastography of the Pancreas: Reference Values and Clinical Feasibility. Invest Radiol. 2020 May;55(5):270-276. doi: 10.1097/RLI.0000000000000638. PMID: 31985600.

  • Wang S, Hesse B, Roman M, Stier D, Castillo-Michel H, Cotte M, Suuronen JP, Lagrange A, Radbruch H, Paul F, Taupitz M, Schellenberger E, Sack I, Infante-Duarte C. Increased Retention of Gadolinium in the Inflamed Brain After Repeated Administration of Gadopentetate Dimeglumine: A Proof-of-Concept Study in Mice Combining ICP-MS and Micro- and Nano-SR-XRF. Invest Radiol. 2019 Oct;54(10):617-626. doi: 10.1097/RLI.0000000000000571. PMID: 31033673.

  • Mayer J, Brown R, Thielemans K, Ovtchinnikov E, Pasca E, Atkinson D, Gillman A, Marsden P, Ippoliti M, Makowski M, Schaeffter T, Kolbitsch C. Flexible numerical simulation framework for dynamic PET-MR data. Phys Med Biol. 2020 Jul 21;65(14):145003. doi: 10.1088/1361-6560/ab7eee. PMID: 32692725.

  • Mayer J, Wurster TH, Schaeffter T, Landmesser U, Morguet A, Bigalke B, Hamm B, Brenner W, Makowski MR, Kolbitsch C. Imaging coronary plaques using 3D motion-compensated [18F]NaF PET/MR. Eur J Nucl Med Mol Imaging. 2021 Jul;48(8):2455-2465. doi: 10.1007/s00259-020-05180-4. Epub 2021 Jan 21. PMID: 33474584; PMCID: PMC8241750.

  • Ippoliti M, Lukas M, Brenner W, Schaeffter T, Makowski MR, Kolbitsch C. 3D nonrigid motion correction for quantitative assessment of hepatic lesions in DCE-MRI. Magn Reson Med. 2019 Nov;82(5):1753-1766. doi: 10.1002/mrm.27867. Epub 2019 Jun 22. PMID: 31228296; PMCID: PMC6771884.

  • Ippoliti M, Lukas M, Brenner W, Schatka I, Furth C, Schaeffter T, Makowski MR, Kolbitsch C. Respiratory motion correction for enhanced quantification of hepatic lesions in simultaneous PET and DCE-MR imaging. Phys Med Biol. 2021 Apr 27;66(9). doi: 10.1088/1361-6560/abf51e. PMID: 33823503.