Proteoglycans and glycosaminoglycans as targets for non-invasive imaging of rupture-prone arteriosclerotic plaques
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Project content
Ruptures of arteriosclerotic plaques cause life-threatening complications such as stroke and myocardial infarction. Non-invasive methods for identifying plaques at risk of rupture would be of great value for better diagnosis and treatment management. Glycosaminoglycans have been identified by us as a potential diagnostic target in atherosclerosis. We hypothesise that plaque instability correlates with a specific pattern of glycosaminoglycans. This project aims to identify instability-associated glycosaminoglycans and evaluate their potential as targets for non-invasive imaging of rupture-prone atherosclerotic plaques.
Publications
- Paysen H, Loewa N, Stach A, Wells J, Kosch O, Twamley S, Makowski MR, Schaeffter T, Ludwig A, Wiekhorst F. Cellular uptake of magnetic nanoparticles imaged and quantified by magnetic particle imaging. Sci Rep. 2020 Feb 5;10(1):1922. doi: 10.1038/s41598-020-58853-3. PMID: 32024926; PMCID: PMC7002802.
- Möckel J, Brangsch J, Reimann C, Kaufmann JO, Sack I, Mangarova DB, Kader A, Taupitz M, Adams LC, Keller S, Ludwig A, Hamm B, Botnar RM, Makowski MR. Assessment of Albumin ECM Accumulation and Inflammation as Novel In Vivo Diagnostic Targets for Multi-Target MR Imaging. Biology (Basel). 2021 Sep 27;10(10):964. doi: 10.3390/biology10100964. PMID: 34681063; PMCID: PMC8533611.
- Freise C, Querfeld U, Ludwig A, Hamm B, Schnorr J, Taupitz M. Uraemic extracellular vesicles augment osteogenic transdifferentiation of vascular smooth muscle cells via enhanced AKT signalling and PiT-1 expression. J Cell Mol Med. 2021 Jun;25(12):5602-5614. doi: 10.1111/jcmm.16572. Epub 2021 May 7. PMID: 33960650; PMCID: PMC8184672.
- Poller WC, Löwa N, Schleicher M, Münster-Wandowski A, Taupitz M, Stangl V, Ludwig A, Wiekhorst F. Initial interaction of citrate-coated iron oxide nanoparticles with the glycocalyx of THP-1 monocytes assessed by real-time magnetic particle spectroscopy and electron microscopy. Sci Rep. 2020 Feb 27;10(1):3591. doi: 10.1038/s41598-020-60162-8. PMID: 32107402; PMCID: PMC7046775.
- Wells J , Twamley S , Sekar A , Ludwig A , Paysen H , Kosch O , Wiekhorst F . Lissajous scanning magnetic particle imaging as a multifunctional platform for magnetic hyperthermia therapy. Nanoscale. 2020 Sep 21;12(35):18342-18355. doi: 10.1039/d0nr00604a. Epub 2020 Sep 1. PMID: 32869808.
- Dehlinger A, Seim C, Stiel H, Twamley S, Ludwig A, Kördel M, Grötzsch D, Rehbein S, Kanngießer B. Laboratory Soft X-Ray Microscopy with an Integrated Visible-Light Microscope-Correlative Workflow for Faster 3D Cell Imaging. Microsc Microanal. 2020 Dec;26(6):1124-1132. doi: 10.1017/S1431927620024447. PMID: 33023699.