CRC 1340 - Matrix in Vision 

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Krankheitsbedingt Veränderungen der Extrazellulärmatrix der Multiplen Sklerose im Mausmodell.

Investigation of the disease-related alteration of the extracellular matrix in a mouse model of multiple sclerosis using molecular and biophysical MRI

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Project content

During brain development, but also in neuroinflammatory processes such as multiple sclerosis (MS), changes in the composition of the extracellular matrix (ECM) occur. In this project, the mechanisms of pathological and regenerative ECM changes in the brain will be investigated for ECM-specific molecular and biophysical imaging. Using an MS mouse model, the accumulation of magnetic nanoparticles in diseased tissue will be correlated with multiscale elastography parameters. In combination with experiments on cell cultures and tissue sections, in vivo imaging will provide information on which biochemical and biophysical tissue properties are suitable as biomarkers for ECM-targeted imaging in inflammatory diseases.

Our team

Project Lead:
PD Dr. med. Carmen Infante-Duarte
Prof. Dr. rer. nat. Ingolf Sack

PhD Candidates (PhD) and Postdoctoral Researchers (PostDoc):
 

Publications

  • Wang S, Hesse B, Roman M, Stier D, Castillo-Michel H, Cotte M, Suuronen JP, Lagrange A, Radbruch H, Paul F, Taupitz M, Schellenberger E, Sack I, Infante-Duarte C. Increased Retention of Gadolinium in the Inflamed Brain After Repeated Administration of Gadopentetate Dimeglumine: A Proof-of-Concept Study in Mice Combining ICP-MS and Micro- and Nano-SR-XRF. Invest Radiol. 2019 Oct;54(10):617-626. doi: 10.1097/RLI.0000000000000571. PMID: 31033673.
  • Guo J, Bertalan G, Meierhofer D, Klein C, Schreyer S, Steiner B, Wang S, Vieira da Silva R, Infante-Duarte C, Koch S, Boehm-Sturm P, Braun J, Sack I. Brain maturation is associated with increasing tissue stiffness and decreasing tissue fluidity. Acta Biomater. 2019 Nov;99:433-442. doi: 10.1016/j.actbio.2019.08.036. Epub 2019 Aug 23. PMID: 31449927.
  • Wang S, Millward JM, Hanke-Vela L, Malla B, Pilch K, Gil-Infante A, Waiczies S, Mueller S, Boehm-Sturm P, Guo J, Sack I, Infante-Duarte C. MR Elastography-Based Assessment of Matrix Remodeling at Lesion Sites Associated With Clinical Severity in a Model of Multiple Sclerosis. Front Neurol. 2020 Jan 13;10:1382. doi: 10.3389/fneur.2019.01382. PMID: 31998225; PMCID: PMC6970413.
  • Millward JM, Ramos Delgado P, Smorodchenko A, Boehmert L, Periquito J, Reimann HM, Prinz C, Els A, Scheel M, Bellmann-Strobl J, Waiczies H, Wuerfel J, Infante-Duarte C, Chien C, Kuchling J, Pohlmann A, Zipp F, Paul F, Niendorf T, Waiczies S. Transient enlargement of brain ventricles during relapsing-remitting multiple sclerosis and experimental autoimmune encephalomyelitis. JCI Insight. 2020 Nov 5;5(21):e140040. doi: 10.1172/jci.insight.140040. PMID: 33148886; PMCID: PMC7710287.

Projects