CRC 1340 - Matrix in Vision 

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Diese Darstellung zeigt die Extrazellulärmatrix mit gestörtem Phosphatmetabolismus.

The pathologically altered extracellular matrix in disturbed phosphate metabolism as a target structure for in vivo imaging

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Project content

An elevated serum phosphate level is associated with functional disorders in the heart. The pathomechanism for this is not clear. Our own experimental preliminary work on this shows a high content of glycosaminoglycans in the heart muscle. This experimental project investigates the hypothesis that glycosaminoglycan-targeted imaging probes and elastographic techniques can be used for in vivo imaging characterisation of hyperphosphataemia-induced myocardial changes. Quantitative physical and biochemical analytical methods are used as reference.

Our team

Project Lead:
Prof. Dr. med. Matthias Taupitz
Dr. med. vet. Jörg Schnorr

PhD Candidates (PhD) and Postdoctoral Researchers (PostDocs):
Julia Hahndorf (PhD)

Publications

  • Freise C, Zappe A, Löwa N, Schnorr J, Pagel K, Wiekhorst F, Taupitz M. Uremic Toxin-Induced Exosome-like Extracellular Vesicles Contain Enhanced Levels of Sulfated Glycosaminoglycans which Facilitate the Interaction with Very Small Superparamagnetic Iron Oxide Particles. Int J Mol Sci. 2023 Sep 18;24(18):14253. doi: 10.3390/ijms241814253. PMID: 37762555; PMCID: PMC10532171.
  • Poller WC, Löwa N, Schleicher M, Münster-Wandowski A, Taupitz M, Stangl V, Ludwig A, Wiekhorst F. Initial interaction of citrate-coated iron oxide nanoparticles with the glycocalyx of THP-1 monocytes assessed by real-time magnetic particle spectroscopy and electron microscopy. Sci Rep. 2020 Feb 27;10(1):3591. doi: 10.1038/s41598-020-60162-8. PMID: 32107402; PMCID: PMC7046775.

  • Freise C, Querfeld U, Ludwig A, Hamm B, Schnorr J, Taupitz M. Uraemic extracellular vesicles augment osteogenic transdifferentiation of vascular smooth muscle cells via enhanced AKT signalling and PiT-1 expression. J Cell Mol Med. 2021 Jun;25(12):5602-5614. doi: 10.1111/jcmm.16572. Epub 2021 May 7. PMID: 33960650; PMCID: PMC8184672.

  • Silva RV, Morr AS, Mueller S, Koch SP, Boehm-Sturm P, Rodriguez-Sillke Y, Kunkel D, Tzschätzsch H, Kühl AA, Schnorr J, Taupitz M, Sack I, Infante-Duarte C. Contribution of Tissue Inflammation and Blood-Brain Barrier Disruption to Brain Softening in a Mouse Model of Multiple Sclerosis. Front Neurosci. 2021 Aug 23;15:701308. doi: 10.3389/fnins.2021.701308. PMID: 34497486; PMCID: PMC8419310.

  • Uca YO, Hallmann D, Hesse B, Seim C, Stolzenburg N, Pietsch H, Schnorr J, Taupitz M. Microdistribution of Magnetic Resonance Imaging Contrast Agents in Atherosclerotic Plaques Determined by LA-ICP-MS and SR-μXRF Imaging. Mol Imaging Biol. 2021 Jun;23(3):382-393. doi: 10.1007/s11307-020-01563-z. Epub 2020 Dec 7. PMID: 33289060; PMCID: PMC8099766.

Projects