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Darstellung der Micro-XRF Karte von Zellgewebe einer Maus.

X-ray microscopy and spectroscopy for speciation of the chemical environment of metal-based imaging probes

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Project content

© B. Kanngießer - TU Berlin

This project will use various X-ray-based analytical techniques for the localisation and chemical speciation of intravenously injected metal-based imaging probes in tissues with pathologically altered extracellular matrix (ECM). These are laboratory X-ray microscopy with 3D localisation, correlative fluorescence microscopy to link structural information with functional data of the corresponding tissue region, and spectroscopic X-ray scanning techniques at the synchrotron as well as detection of chemical states of iron oxide nanoparticles with sub-µm resolution. The instrument development represents a main point for the establishment of an adapted analytical workflow within the SFB to analyse the interaction of the imaging probes with components of the ECM.

Our team

Project Lead:
Prof. Dr. rer. nat. Birgit Kanngießer
Dr. rer. nat. Christian Seim

PhD Candidates (PhD) and Postdoctoral Researchers (PostDocs):
Dr. rer. nat. Aurelie Dehlinger (PostDoc)


  • Dehlinger A, Seim C, Stiel H, Twamley S, Ludwig A, Kördel M, Grötzsch D, Rehbein S, Kanngießer B. Laboratory Soft X-Ray Microscopy with an Integrated Visible-Light Microscope-Correlative Workflow for Faster 3D Cell Imaging. Microsc Microanal. 2020 Dec;26(6):1124-1132. doi: 10.1017/S1431927620024447. PMID: 33023699.