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Projektübersicht A02

Magnetic Particle Imaging for imaging the extracellular matrix

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Project content

Magnetic Particle Imaging (MPI) is a new quantitative method for specific imaging of magnetic nanoparticles. Our own preliminary experimental work shows the suitability of magnetic nanoparticles as glycosaminoglycan-directed probes for imaging processes in the extracellular matrix. This experimental project investigates the hypothesis that MPI can be used to indirectly visualise biomolecular processes of the pathologically altered extracellular matrix with high spatial and temporal resolution based on the dynamic behaviour of magnetic nanoparticles. Quantitative physical and biochemical analytical methods are used as a reference in the network.

Our team

Project Lead:
Dr. rer. nat. Frank Wiekhorst (PTB)
Prof. Dr. med. Matthias Taupitz (Charité)

PhD Candidates (PhD) and Postdoctoral Researchers (PostDoc):
Dr. rer. nat. James Wells (PostDoc)


  • Mangarova DB, Brangsch J, Mohtashamdolatshahi A, Kosch O, Paysen H, Wiekhorst F, Klopfleisch R, Buchholz R, Karst U, Taupitz M, Schnorr J, Hamm B, Makowski MR. Ex vivo magnetic particle imaging of vascular inflammation in abdominal aortic aneurysm in a murine model. Sci Rep. 2020 Jul 24;10(1):12410. doi: 10.1038/s41598-020-69299-y. PMID: 32709967; PMCID: PMC7381631.

  • Kratz H, Mohtashamdolatshahi A, Eberbeck D, Kosch O, Wiekhorst F, Taupitz M, Hamm B, Stolzenburg N, Schnorr J. Tailored Magnetic Multicore Nanoparticles for Use as Blood Pool MPI Tracers. Nanomaterials (Basel). 2021 Jun 10;11(6):1532. doi: 10.3390/nano11061532. PMID: 34200588; PMCID: PMC8228684.

  • Mohtashamdolatshahi A, Kratz H, Kosch O, Hauptmann R, Stolzenburg N, Wiekhorst F, Sack I, Hamm B, Taupitz M, Schnorr J. In vivo magnetic particle imaging: angiography of inferior vena cava and aorta in rats using newly developed multicore particles. Sci Rep. 2020 Oct 14;10(1):17247. doi: 10.1038/s41598-020-74151-4. PMID: 33057029; PMCID: PMC7560824.

  • Kratz H, Mohtashamdolatshahi A, Eberbeck D, Kosch O, Hauptmann R, Wiekhorst F, Taupitz M, Hamm B, Schnorr J. MPI Phantom Study with A High-Performing Multicore Tracer Made by Coprecipitation. Nanomaterials (Basel). 2019 Oct 16;9(10):1466. doi: 10.3390/nano9101466. PMID: 31623127; PMCID: PMC6835925.

  • Paysen H, Loewa N, Stach A, Wells J, Kosch O, Twamley S, Makowski MR, Schaeffter T, Ludwig A, Wiekhorst F. Cellular uptake of magnetic nanoparticles imaged and quantified by magnetic particle imaging. Sci Rep. 2020 Feb 5;10(1):1922. doi: 10.1038/s41598-020-58853-3. PMID: 32024926; PMCID: PMC7002802.

  • Poller WC, Löwa N, Schleicher M, Münster-Wandowski A, Taupitz M, Stangl V, Ludwig A, Wiekhorst F. Initial interaction of citrate-coated iron oxide nanoparticles with the glycocalyx of THP-1 monocytes assessed by real-time magnetic particle spectroscopy and electron microscopy. Sci Rep. 2020 Feb 27;10(1):3591. doi: 10.1038/s41598-020-60162-8. PMID: 32107402; PMCID: PMC7046775.

  • Wells J , Twamley S , Sekar A , Ludwig A , Paysen H , Kosch O , Wiekhorst F . Lissajous scanning magnetic particle imaging as a multifunctional platform for magnetic hyperthermia therapy. Nanoscale. 2020 Sep 21;12(35):18342-18355. doi: 10.1039/d0nr00604a. Epub 2020 Sep 1. PMID: 32869808.
  • Hildebrand S, Löwa N, Paysen H, Fratila RM, Reverte-Salisa L, Trakoolwilaiwan T, Niu Z, Kasparis G, Preuss SF, Kosch O, M de la Fuente J, Thanh NTK, Wiekhorst F, Pfeifer A. Quantification of Lipoprotein Uptake in Vivo Using Magnetic Particle Imaging and Spectroscopy. ACS Nano. 2021 Jan 26;15(1):434-446. doi: 10.1021/acsnano.0c03229. Epub 2020 Dec 11. PMID: 33306343.
  • Baki A, Remmo A, Löwa N, Wiekhorst F, Bleul R. Albumin-Coated Single-Core Iron Oxide Nanoparticles for Enhanced Molecular Magnetic Imaging (MRI/MPI). Int J Mol Sci. 2021 Jun 9;22(12):6235. doi: 10.3390/ijms22126235. PMID: 34207769; PMCID: PMC8229057.
  • Löwa N, Gutkelch D, Welge EA, Welz R, Meier F, Baki A, Bleul R, Klein T, Wiekhorst F. Novel Benchtop Magnetic Particle Spectrometer for Process Monitoring of Magnetic Nanoparticle Synthesis. Nanomaterials (Basel). 2020 Nov 17;10(11):2277. doi: 10.3390/nano10112277. PMID: 33213004; PMCID: PMC7698567.
  • Baki A, Löwa N, Remmo A, Wiekhorst F, Bleul R. Micromixer Synthesis Platform for a Tuneable Production of Magnetic Single-Core Iron Oxide Nanoparticles. Nanomaterials (Basel). 2020 Sep 15;10(9):1845. doi: 10.3390/nano10091845. PMID: 32942715; PMCID: PMC7560047.
  • Wells J, Paysen H, Kosch O, Wiekhorst F. Heat dissipation and safety considerations during Lissajous scanning magnetic particle imaging. International Journal on Magnetic Particle Imaging. 2020; 6(2 Suppl 1).
  • Paysen H, Kosch O, Wells J, Loewa N, Wiekhorst F. Characterization of noise and background signals in a magnetic particle imaging system. Phys Med Biol. 2020 Oct 21. doi: 10.1088/1361-6560/abc364. Epub ahead of print. PMID: 33086200.